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ePaper created 2017-03-14, 10:25:37 | version 1.49.03
L / g n i n o i t a r t n e c n o c d i c a c i n o c a t i 140 120 100 80 60 40 20 0 shake lask 100 L 300 L 1 m3 0 24 48 72 96 120 144 168 192 216 240 264 288 312 cultivation time in h 2 10 μm 3 Contact Dr.-Ing. Katja Patzsch Phone +49 3461 43-9104 katja.patzsch@cbp.fraunhofer.de Dr.-Ing. Susanne Zibek Phone +49 711 970-4167 susanne.zibek@igb.fraunhofer.de Literature [1] Hevekerl, A.; Kuenz, A.; Vorlop, K.-D. (2014) Inluence of the pH on the itaconic acid production with Aspergillus terreus, Appl Microbiol Biotechnol 98: 10005 – 10012 Scale-up The scale-up of the fermentation process is being carried out at Fraunhofer CBP. The protocols were transferred to the scales 100 liters, 300 liters and 1 m³ (total volume). The fermentation processes at the 100 liter and 300 liter scales achieved comparable results regarding itaconic acid produc- tion and glucose consumption (Fig. 3). The 1 m3 scale resulted in a somewhat lower itaconic acid production since the fungus morphology changes slightly with higher fermentation volume. Whereas A. terreus grows in pellet form up to the 300 liter scale, the growth form was more mycelial at the 1 m³ scale. Therefore, we are currently working on adjusting scale-up parameters to ensure consistent morphology of the fungus. Further work will consider the transfer of the fermentation The project “Bio-QED – Quod Erat Demonstrandum: Large Funding process to other sugar substrates, an additional scale-up to 10 m3 and the development of product preparation at a pilot scale. scale demonstration for the bio-based bulk chemicals BDO and IA aiming at cost reduction and improved sustainability” has received funding from the European Union’s Seventh Framework Programme for research, technological development and demon- stration under grant agreement no 613941. Project partners Novamont, Italy | Mater Biotech, Italy | Cargill, Belgium | TNO, the Netherlands | Itaconix, USA | Lubrizol Advanced Materi- als S.L., Spain | MiPlast, Croatia | VLCI, the Netherlands | 1 Added value chains of the Bio-QED Patentopolis, the Netherlands | nova-Institut für politische und project. 2 Microscope image of the fungus Aspergillus terreus. 3 Itaconic acid production at different production scales. ökologische Innovation GmbH, Germany | Rina Services, Italy Further information www.bio-qed.eu 7 5