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ePaper created 2017-03-14, 10:25:37 | version 1.49.03
COMPETENCES CELL AND TISSUE ENGINEERING The department creates biomedical solutions using principles from tissue engineering and regenerative medicine. A focus is on the development and testing of innovative biomaterials for medical engineering, another on the development of human test systems as alternative to animal experiments. We use human isolated primary cells and induced pluripotent stem (iPS) cells to establish 2D / 3D in vitro tissue models. We leverage microluidic technology to develop organ-on-a-chip systems as validated high-throughput screening tests for drug candidates. Research focus Design and modiication of biocompatible hybrid materials as carrier substrates for medical engineering Investigation of cell-material interactions Click chemistry for the coupling of extracellular matrix proteins to surfaces Skin models of varying complexity as test systems for cosmetics and drugs Validation and parallelization of organ-on-a-chip systems (heart muscle cells, white fat tissue) for drug candidates testing Technology and expertise Tissue engineering using tissue-speciic human primary Bioprinting of human 3D tissues Cardiovascular tissue engineering: test tissues, cells as well as adult, embryonic* and induced-pluripotent stem cells (iPS cells) for development of 3D tissue models Patented 3D human skin equivalent Microluidic organ-on-a-chip systems Accredited in vitro cytotoxicity testing of R&D materials regenerative molecular and cell therapies, implants for heart muscle and heart valves and industrial products (DIN ISO 10993-5) Contact Accredited phototoxicity testing of substances Development and modiication of biomaterials (electrospinning, hydrogels, extracellular matrix) Production of human recombinant extracellular matrix proteins Non-invasive characterization of cells and tissues using Raman microspectroscopy * Approved by the Robert Koch-Institute AZ: 3.04.02 / 0086 and 3.04.02 / 0111 3 8 Prof. Dr. rer. nat. Katja Schenke- Layland Head of Department, Director (acting, executive) Phone +49 711 970-4082 katja.schenke-layland@igb.fraun hofer.de Prof. Dr. rer. nat. Petra Kluger Head of Department Phone +49 711 970-4072 petra.kluger@igb.fraunhofer.de