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ePaper created 2017-03-14, 10:25:37 | version 1.49.03
2 3 Contact Production of a drug release system In addition to the manufacture of implants and test systems, we are working on systems that can release drugs, proteins or growth factors over time. A recent example is the encapsula- tion of glycine-modiied diclofenac in a hydrophobic PLA carrier substrate, which is released continuously over 24 hours [4]. The mechanical properties of PLA were not affected by the encapsulation of the drug. The release experiments showed that approximately 90 percent of the diclofenac is released into the environment. A further release can then only take place via the degrada- tion of the ibers. The drug could be visualized in the ibers via multiphoton microscopy. In addition, we conirmed the biocompatibility of the drug release system using standardized test methods as well as luorescence endurance microscopy (FLIM) in human ibroblasts. The drug-release system, which is produced by means of electrospinning, is suitable as a wound dressing for the treatment of actinic keratosis. Dr. rer. nat. Svenja Hinderer Phone +49 711 970-4196 svenja.hinderer@igb.fraunhofer.de Prof. Dr. rer. nat. Katja Schenke-Layland Phone +49 711 970-4082 katja.schenke-layland@ igb.fraunhofer.de Literature [1] Hinderer, S. et al. (2016) ECM and ECM-like materials – Bio- materials for applications in regenerative medicine and cancer therapy, Advanced Drug Delivery Reviews 97: 260 – 269 [2] Hinderer, S. et al. (2014) Bioengineering of a bio-functional- ized off-the-shelf heart valve, Biomaterials 35: 2130 – 2139 [3] Hinderer, S. et al. (2012) Engineering of ibrillar decorin matrices for a tissue-engineered trachea, Biomaterials 33(21): 5259 – 5266 [4] Piccirillo, G. et al. (2016) Electrospun PLA scaffold for a controlled and targeted delivery of a synthetically obtained Diclofenac prodrug to treat actinic keratosis, Acta Biomaterialia: DOI: http://dx.doi.org/10.1016/j.actbio.2016.11.002 Funding We would like to thank the Fraunhofer-Gesellschaft for funding the “SpinKoll” project as part of the Discover program as well as for funding under the TALENTA speed up program. 1 Electrospinning for the production of ibrous carrier substrates. Further information and project partners 2 Multiphoton microscopy: electrospun carrier www.schenke-layland-lab.com substrate with diclofenac-glycine. 3 Tubular electrospun substrate. 5 7