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ePaper created 2017-03-14, 10:25:37 | version 1.49.03
Coatings and biomaterials for medical technology Properties of the materials and interactions between the material and the biological system are key factors in the manufacture of implants and medical devices. Fraunhofer IGB is developing bioactive, biocompatible or bioinert materials for use in medicine and medical technology, e.g. for stents, catheters and implants. We are testing biocompatibility of the materials using an accredited testing method pursuant to DIN EN ISO 10993-5. For implants, we are investigating cell-material interactions and developing materials such as electrospun, biodegradable ibers or hydrogels that are developed further to bioinks for additive manufacturing of tissue models. In addition to biological carriers, Fraunhofer IGB is also developing miniaturized tubes as supply systems for larger tissue models. Personalized medicine In the ield of personalized medicine, the focus is developing cell-based therapeutics, autolo- gous transplants and biologized implants. Fraunhofer IGB and its Würzburg branch, with the Translational Center for “Regenerative Therapies for Oncology and Musculoskeletal Diseases”, are covering the entire value-added chain right up to GMP-compliant manufacturing of cell- based therapeutics and implants (Advanced Therapy Medicinal Products, ATMPs) and – to- gether with a network of physicians – phase I clinical studies. We are analyzing contaminations of implants using non-destructive techniques with spectroscopic and multiphoton microscopic methods. A new approach to producing dimensionally stable, tissue-like structures (e.g. car- tilage, fat tissue) is being pursued by 3D printing of cells onto UV-crosslinkable hydrogels. For the development of patient- and disease-speciic test systems, Fraunhofer IGB is working on iPS-based organ-on-a-chip systems. Molecular diagnostics Fraunhofer IGB is developing novel molecular biology technologies based on nucleic acids (microarrays, high-throughput DNA sequencing) or using cellular reporter systems (pyrogen assay system) that can be used for clear and unambiguous diagnoses. This information helps to initiate measures for speciic treatments or develop personalized medicines for different popu- lation groups. In particular for combating infectious diseases, the combination of methods of functional genome analysis with our expertise in cell culture technology and infection biology results in a unique position for developing infection models and diagnostics. We have estab- lished a versatile, non-invasive, marker-free diagnostic tool based on Raman microspectroscopy for real-time analysis of cells and tissues. 4 7