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ePaper created 2017-03-14, 10:25:37 | version 1.49.03
1 μm 1 μm air l uid l uid no 1 air l uid no 2 nozzle tip nozzle cap nozzle orii ce 3 Preparation of core-shell particles Insoluble active ingredients must be converted into stable emulsions or suspensions prior to spray drying. High shear forces and stabilizers are usually required, which cause nega- tive interactions depending on the substance. Therefore, the use of the three-l uid nozzle is investigated in this project (Fig. 3). Two mutually independent component streams can be atomized with a gas stream. In the droplets, mixing occurs due to shear forces and the active ingredient is immobilized in the particle on simultaneous drying [1]. Using different materi- als, it is also possible to produce core-shell particles (Fig. 1) – the active substance is embedded in a matrix that is coated with a second material. This provides customized solutions for a wide range of applications. 4 Contact Michael Walz M. Sc. Phone +49 711 970-4118 michael.walz@igb.fraunhofer.de Dr. rer. nat. Achim Weber Phone +49 711 970-4022 achim.weber@igb.fraunhofer.de Literature [1] Kašpar, O.; Tokárová, V.; Nyanhongo, G. S.; Gübitz, G.; Štěpánek, F. (2013) Effect of cross-linking method on the activity of spray-dried chitosan microparticles with immobilized laccase, Food Bioproducts Processing 91: 525 Outlook Funding In further experiments, various combinations of active ingre- dients and materials will be prepared and characterized. The encapsulation of nanoparticles using this process is also an interesting application. We would like to thank the Konrad Adenauer Foundation for awarding us with a doctorate scholarship. Project partner Institute of Interfacial Process Engineering and Plasma Technol- ogy IGVP, University of Stuttgart 1 Core-shell inulin particle, produced by means of a three-l uid nozzle. 2 Schematic illustration of the spray drying [1]. 3 Nozzle design [1]. 4 Comparison of drug-loaded inulin particles with and without modii cation. 5 9