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ePaper created 2017-03-14, 10:25:37 | version 1.49.03
MOLECULAR BIOTECHNOLOGY The biologization of industrial processes is one of the most important issues of the 21st century. New sequencing tech- nologies and proteome analyses, the targeted modiication of organisms of all species and the development of enzymatic or fermentative production processes provide new ways for the production of ine and bulk chemicals as well as for the development of diagnostics and therapeutics. We apply these new technologies for the development of diagnostics in infec- ¡ Host-pathogen infection models (3D tissue models) ¡ Target and drug screening Diagnostics ¡ Diagnostic microarrays ¡ Next-generation diagnostics ¡ Cell-based assays Therapeutic proteins ¡ Production cell lines for recombinant production of e.g. tion research and in personalized medicine as well as in the interferons, factor VII development of antimicrobial drugs and for the production of therapeutic proteins. In the ield of industrial biotechnology, we convert renewable raw materials to new products for the chemical industry using biotechnological processes. Technology and expertise Molecular-biological worklows for clinical samples Diagnostic microarrays Next-generation sequencing (NGS) Bioinformatic worklows for NGS data Development of stable cell lines and production strains Cell-based assays, e.g. antiviral and pyrogen detection assays (GLP), and complex 3D infection models Virus-like particles and therapeutic viruses Protein puriication and characterization Strain and enzyme screening Development and scale-up of bioprocesses and fermentation processes Chemico-physical and biochemical analysis Research focus Infection biology ¡ Mycology – pathogenic Candida spp. ¡ Virology – herpes viruses, polio Enzyme screening and characterization ¡ Ligninolytic enzymes, hydrolases, oxidoreductases Fermentation processes for industrial biotechnology ¡ Enzyme production ¡ Platform chemicals, e.g. furan dicarboxylic acid, itaconic acid, maleic acid, long-chain dicarboxylic acids ¡ Microbial biosurfactants ¡ Scale-up Processing of raw and residual materials for industrial biotechnology ¡ Processing of lignocellulosic material ¡ Vegetable fats and oils ¡ Isolation of chitin derivatives from waste materials Isolation of natural products Contact apl. Prof. Dr. Steffen Rupp Head of Department, Deputy Director Phone +49 711 970-4045 steffen.rupp@igb.fraunhofer.de 3 5