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ePaper created 2014-05-07, 13:23:14 | version 1.30.01
87 Angela Mattes B.Sc. Phone +49 711 970-4029 angela.mattes@igb.fraunhofer.de Dr. Anke Burger-Kentischer Phone +49 711 970-4023 anke.burger-kentischer@igb.fraun hofer.de References [1] Akira, S.; Takeda, K. (2004) Nat Rev Immunol 4: 499 – 511 [2] Akira, S.; Uematsu, S.; Takeuchi, O. (2006) Cell 124: 783 – 801 [3] Vasilakos, J. P.; Tomai, M.A. (2013) Expert Rev. Vaccines 12: 809 – 19 [4] Burger-Kentischer, A.; Abele, I. S.; Finkelmeier, D.; Wiesmüller, K. H.; Rupp, S. (2010) J Immunol. Methods 358: 93 – 103 [5] Zellbasiertes Testsystem zur Identifizierung und Differenzier- ung von Keimspektren (2009) Patent DE 10 2006 031 483; EP 2 041 172 [6] Zhou, W. et al. (2013) Theor. Biol. Med. Model. 10: 18 Funding We would like to thank the Fraunhofer-Gesellschaft for fund- ing the project “Discovery and delivery of PRR antagonists and agonists to regulate innate immune reaction” within the ICON program. Project partner Hebrew University of Jerusalem, Institute for Drug Research (IDR), Jerusalem, Israel the experts at the Hebrew University, using the data gained by the IGB, and finally tested again at the IGB. Outlook The molecules identified with the aid of the cell-based assay at the IGB represent potential drug candidates for the preven- tion and therapy of immunological diseases. The complement- ing expertise of the partners, the unique, patented procedure for molecular simulation by the Hebrew University and the cell-based TLR screening assay developed at the IGB, have provided significant added value regarding the chances of this challenging aim: to find new TLR-based immunomodulators for the therapy and prevention of various medical indications. 1 Cell-culture flasks. 2 Schematic representation of the cell-based reporter gene assay. 3 Structure of the human TLR9 when bound to the antagonist ODN (receptor-antagonist-complex) [6]. 4 Cell-based reporter gene assay in cell-culture plates. 3 4 NT CT Contacts