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2013|14 Annual Report Fraunhofer IGB

85 Dipl.-Biol. (t.o.) Sibylle Thude Phone +49 711 970-4152 sibylle.thude@igb.fraunhofer.de Prof. Dr. Katja Schenke-Layland Phone +49 711 970-4082 katja.schenke-layland@ igb.fraunhofer.de References [1] Weedon, D. (2010) Weedon‘s Skin Pathology (Third Edition), Churchill Livingstone, Edinburgh, 667 – ​708 [2] Sidoroff, A.; Thaler, P. (2010) Taking treatment decisions in non-melanoma skin cancer – The place for topical photodynamic therapy (PDT), Photodiagnosis and Photodynamic Therapy, 7: 24 – ​ 32, doi: 10.1016 / ​j.pdpdt.2009.12.004 [3] Brauchle, E.; Johannsen, H.; Nolan, S.; Thude, S.; Schenke- Layland, K. (2013) Biomaterials 34: 7401 – ​7407 Funding We would like to thank the Fraunhofer-Gesellschaft for funding the project “SkinCancer” within the scope of its internal SME- oriented research program (MEF). New model for optimization of photodynamic therapy There is now an in vitro model of squamous cell carcinoma that can be mapped to the different tumor stages, which are comparable to the in vivo situation in humans. Because we can clearly distinguish healthy and diseased cells, it is possible to investigate new photosensitizing substances and their effects on healthy and sick cells. We can further use the model to test different irradiation protocols for photodynamic therapy and develop comparative studies of various radiation sources to apply to the tumor cells more effectively. Further- more, the model can be used for the development of new photosensitizer formulations that reach tumor cells located in the deep layers of the skin. 2 1 The in vitro construction of healthy skin models and the different stages of squamous cell carcinoma. A: epidermis models, B: full thickness skin models. 2 Comparison of the in vivo situation with the in vitro model of squamous cell carcinoma. Early stage: bugle beads-like structures as they occur in vivo. Late stage: tumor nests. in vivo in vitro healthy diseased: early stage diseased: late stage Contacts

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