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ePaper created 2014-05-07, 13:23:14 | version 1.30.01
75 Svenja Hinderer M.Sc. Phone +49 711 970-4196 svenja.hinderer@igb.fraunhofer.de Shannon Lee Layland B.A. Phone +49 711 970-4283 shannon.layland@igb.fraunhofer.de Reference [1] Hinderer, S.; Seifert, J.; Votteler, M.; Shen, N.; Rheinlaender, J.; Schäffer, T. E.; Schenke-Layland, K. (2013) Engineering of a bio-functionalized hybrid off-the-shelf heart valve, Biomaterials 35(7): 2130 – 2139 Funding We would like to thank the Fraunhofer-Gesellschaft for support of the Attract Group to develop cardiovascular regeneration technologies and the California Institute for Regenerative Medi- cine (CIRM) and the German Federal Ministry of Education and Research (BMBF) for funding the project “Characterization and Bioengineering of the cardiac stem cell niche”. Project partners University Hospital for Women of the Eberhard Karls University of Tübingen | IGVP, University of Stuttgart | University of Califor- nia Los Angeles (UCLA), Los Angeles, CA, USA Further information www.schenke-layland-lab.com Outlook Mimicking the structure and mechanical properties of the na- tive heart valve, as well as using proteins to “attract” cells in vivo, enables the production of a cell-free off-the-shelf prod- uct. The previous limitations of cardiac valve replacement sys- tems, such as the thickening and shortening of valve leaflets or the lack of growth for pediatric patients, may be resolved. Current approaches to cardiac regeneration, such as injecting stem cells into the heart muscle, have shown modest clinical improvement in function, but at increasing production costs. Injecting the matrix proteins produced in our lab provides a way to stimulate the regeneration potential of the heart muscle at lower costs and risks to the patient. It is planned to produce the proteins under GMP conditions for use in clinical applications. 1 An electrospun-based substrate is stitched into a porcine heart valve. 2 Electrospun polymer on a heart valve shaped copper collector. 3 Scanning electron microscopy image of valve cells (purple) seeded on an electrospun scaffold. 2 3 Contacts