2012|13 Annual Report Fraunhofer IGB

Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB Project Group Oncology c / o University of Würzburg Chair of Tissue Engineering and Regenerative Medicine Röntgenring 11 | 97070 Würzburg | Germany Prof. Dr. Heike Walles Phone +49 931 31-88828 Fax +49 931 31-81068 heike.walles@igb.fraunhofer.de Contact Range of services Production and biochemical modiﬁcation of tissue engi- neered electrospun 3D scaffolds Isolation of primary human stem and tumor cells Establishment of co-cultures for the generation of human solid tumors in vitro and tumor test systems Development of speciﬁc bioreactors for various tumor models Development of human vascularized tumor tissue for the establishment of individual diagnostics and personalized treatments Biological cell analysis of tumor tissue: molecular-biologi- cal, histological and immunohistochemical methods, ﬂow cytometry (FACS), including sorting Target screening for new cancer therapeutics Our research services can be used for the entire value-added chain in the development of cancer therapies: Investigation of the active principle and/or the side effects of new drug candidates utilizing vascularized human tu- mor test systems Use of the tumor model in the process development of optimizing drugs or diagnostics Implementation and validation of in vitro tests as alterna- tives to animal testing at the end of the preclinical devel- opment phase Efﬁcacy experiments of new drugs that are currently undergoing evaluation for clinical use Cooperation with the medical faculty of Würzburg for the organization of the clinical phases I–III Infrastructure and technical equipment Cell culture laboratories for work on safety levels S1 and S2 GenTSV Cell analysis: Fluorescence microscope, FACS, microdissec- tion system, Raman spectroscopy 57

2012|13 Annual Report Fraunhofer IGB

Pages