Please activate JavaScript!
Please install Adobe Flash Player, click here for download
ePaper created 2016-03-17, 15:06:18 | version 1.45.01
79 Priv.-Doz. Dr. sc. nat Susanne Bailer Phone +49 711 970-4180 susanne.bailer@igb.fraunhofer.de Contact Funding We would like to thank the Fraunhofer-Gesellschaft for funding the project “Vari-VLP” in the SME-oriented internal research program. Efficient and cost-effective VLP platform technology As the basis for a VLP platform technology, non-enveloped viruses of the Caliciviridae family were chosen. To synthesize the VLPs in Baker´s yeast, plasmids were developed coding for the virus protein variants. Baker´s yeast is particularly well suited for the production of VPLs, because proteins for pharmaceutical applications can be produced with minimal side effects and in a cost-effective manner in this organism. In this way, a VLP basic structure could already be developed and characterized with success. Thus, a system is available for the expression and isolation of native caliciviral VLPs, so that a downstream processing can now be established. The aim is to establish an efficient and cost-effective process based on these VLPs that will make it possible to produce such biocontainers in great quantities and with high purity and homogeneity. Outlook A modular system and an accordingly standardized process have a wide range of applications and the demand on the market is high. In addition to multinational corporations, SMEs in particular are sharing the pharmaceutical market for drug delivery and vaccine development. 1 Standardized production of VLPs. analysis structure assembly Phone +49711970-4180