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ePaper created 2016-03-17, 15:06:18 | version 1.45.01
69 Dr. rer. nat. Eva Brauchle Phone +49 711 970-4196 eva.brauchle@igb.fraunhofer.de Dr. rer. nat. Svenja Hinderer Phone +49 711 970-4196 svenja.hinderer@igb.fraunhofer.de Contact Literature [1] Hinderer, S. et al. (2015) In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber- containing extracellular matrix scaffold, Biomed Mater 10: 034102 [2] Hinderer, S. et al. (2014) Bioengineering of a bio-functional- ized off-the-shelf heart valve, Biomaterials 35: 2130–2139 Brauchle, et al ovel non-invasive chamber-specific identification of cardiomyocytes in differentiating pluripotent stem cells. Stem Cell Reports 6: 1–12 Funding We thank the German Federal Ministry of Education and Research (BMBF) for funding the project “Characterization and Bioengineering of cardiac stem cell niche”, promotional reference 1316059, the European Union for supporting the research proj- ect “AMCARE”, grant agreement no NMP3-SME-2013-604531, and the Fraunhofer-Gesellschaft for supporting the project “Renovatum Therapeutics” under the “Fraunhofer promotes start-ups” program (FFE) and the “OptisCell” project under the market-driven prospective research program (MAVO). Further information and project partners www.schenke-layland-lab.com | www.amcare.eu In our work, we demonstrated that the differentiation path of embryonic stem cells to cardiac progenitor cells and then functional cardiomyocytes can be represented using Raman microspectroscopy ell-specific molecular fingerprints of atrial and ventricular murine and human cardiomyocytes can be distinguished, as well as the maturation levels of fetal and adult cardiomyocytes In recent studies, it was confirmed that Raman microspectroscopy could detect the maturation of cardiomyocytes induced by a stretch-flow bioreactor e are currently developing a new bioreactor system, which ad- ditionally meets the optical requirements for carrying out the continuous microspectroscopy. 1 Fluorescence image of mature cardiomyocytes in the bioreactor. 2 Stretch-flow bioreactor system. 3 Histological staining of a human heart. 32 Phone +49711970-4196 Phone +49711970-4196