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61 Prof. Dr. rer. nat. Petra Kluger Phone +49 711 970-4072 petra.kluger@igb.fraunhofer.de Dr. rer. nat. Monika Bach Phone +49 711 685-68304 monika.bach@igb.fraunhofer.de Contact Literature [1] Repenning, D.; Gollwitzer, H (2006) Ossäre Integration, Springer Medizin Verlag Heidelberg [2] Goodman, S. B.; Yao, Z.; Keeney, M.; Yang, F. (2013) The future of biologic coatings for orthopaedic implants, Biomaterials 34(13): 3174–83 [3] Fitzpatrick, L. E.; McDevitt, T. C. (2014) Cell-derived matrices for tissue engineering and regenerative medicine applications, Biomaterial Science 3: 12–24 Funding We thank the Fraunhofer-Gesellschaft for supporting the “clickECM” project under the “Discover” program. Furthermore, we thank the Baden-Württemberg Stiftung for supporting the project “glycomics/glycobiology“. Project partners University of Stuttgart, Institute of Interfacial Process Engineering and Plasma Technology IGVP | University of Konstanz, Depart- ment of Chemistry, Prof. Dr. Valentin Wittmann and Daniel Wieland Outlook In the future, our clickEMC coating could promote the inte- gration of implants into their surrounding tissue. The use of autologous cells for the manufacturing of clickEMC enables the individualized coating of material surfaces. This should significantly improve cell growth on the surface of the implant and reduce inflammation and organ re ection due to the immune system’s foreign body response. Furthermore, it is expected that the improved cell adhesion will accelerate the integration of the implant into the patient and the fi ed bond- ing of the coating will considerably increase the long-term stability of the implant. Another application for clickECM is its use as a coating in cell culture dishes ell-specific M closely mimics the physiologi- cal microenvironment of cells, which could positively influence cell proliferation or differentiation, or prevent undesirable changes in the cells. 1 Cell culture for metabolic oligosaccharide engineering. 2 Fluorescence microscopic detection of azide modification (azides: green). 3 Proof of collagens (yellow) in the clickECM. 4 Isolated ECM after 21 days in vitro culture. (250 mL laboratory glass bottle, 50 µm). 3 450 μm Phone +49711970-4072 Phone +49711685-68304 3450 μm