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2015|16 Annual Report Fraunhofer IGB - DEVELOPMENT OF A FUNCTIONAL THREE-LAYER FULL-SKIN MODEL

1 Mature adipocytes encapsulated in a collagen type I hydrogel. 2 HE staining of a three-layer full-skin model. 3 Cytokeratin 10 (red) and Laminin (green) staining of a full-thickness skin model. 65 Contact Prof. Dr. rer. nat. Petra Kluger Phone +49 711 970-4072 petra.kluger@igb.fraunhofer.de Dr. rer. nat. Kirsten Borchers Phone +49 711 970-4121 kirsten.borchers@igb.fraunhofer.de Literature [1] Huber, B.; Kluger, P. J. (2015) Decelerating mature adipocyte dedifferentiation by media composition, Tissue Engineering Part C Methods 21(12): 1237–45 [2] Annual Report Fraunhofer IGB 2014 [3] Huber, B.; Borchers, K.; Tovar, G. E. M.; Kluger, P. J. (2015) Methacrylated gelatin and mature adipocytes are promising com- ponents for adipose tissue engineering, Journal of Biomaterials Applications 30(6): 699–710 [4] Huber, B.; Volz, A.; Kluger, P. J. (2015) Understanding the cross-talk of mature adipocytes and endothelial cells in physi- ological fatty tissue for vascularized adipose tissue engineering, Cell and Tissue Research 362(2): 269–79 Funding The research project “ArtiVasc 3D” has received funding from European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 263416. Further information and project partners www.artivasc.eu 2 3100 μm Phone +49711970-4072 Phone +49711970-4121 23100 μm

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